Patterns and Determinants of Change in Cortisol Levels and Thyroid Function as a Function of Cardiac Risk in Children Undergoing Cardiac Surgery

Table 3

Effect of cardiac risk category on changes in thyroid function and cortisol levels (Repeated-Measure Analysis of Variance (RM-ANOVA)).

Outcome	Factor	Statistics^§	value	Partial Eta squared	Comment (effect size)
TSH	Time	0.468	<0.001	0.468	Very large effect
		0.073	0.357	0.073	No effect
	Between-subjects	—	0.100	0.060	No effect
fT4	Time	0.466	<0.001	0.466	Very large effect
		0.051	0.524	0.051	No effect
	Between-subjects	—	0.824	0.001	No effect
fT3	Time	0.739	<0.001	0.739	Extremely large effect
		0.064	0.419	0.064	No effect
	Between-subjects	—	0.339	0.021	No effect
Cortisol	Time	0.717	0.003	0.283	Large effect
		0.955	0.595	0.045	No effect
	Between-subjects	—	0.027	0.109	Moderate effect

^§Statistics used was Wilk’s Lambda if both Levene’s test of errors’ variance equality and Box’s test of equality of covariance matrices are verified ( and > 0.01, respectively); otherwise, if either assumption is violated, then Pillai’s Trace statistics was used. Effect size is assumed to be large if partial Eta .