Patterns and Determinants of Change in Cortisol Levels and Thyroid Function as a Function of Cardiac Risk in Children Undergoing Cardiac Surgery

Table 4

Predictors of the change in TSH, T3, T4, and cortisol postcardiac surgery (stepwise linear regression).

Predicted parameter (time)	Predictor	Level	OR	95% CI	value
TSH (24 h)	DHCA time	(min)	0.67	0.55-0.82	<0.001	0.296
	RACHS	<3	0.18	0.03-0.99	0.049
fT3 (24 h)	Bypass time	(>70 min)	0.29	0.11-0.80	0.017	0.124
fT3 (48 h)	Gender	Female	0.33	0.12-0.90	0.031	0.104
fT4 (24 h)	Age	(Month)	1.03	1.00-1.06	0.023	0.114
fT4 (48 h)	AKI	Yes	0.04	0.00-0.53	0.016	0.269
	Age	(Month)	1.03	1.00-1.05	0.035
Cortisol (24 h)	Bypass time	(>70 min)	[499.66]	[162.00]-[837.32]	0.005	0.296
	Delayed sternal closure	Yes	[609.65]	[170.79]-[837.32]	0.008

AKI: acute kidney injury; OR: odds ratio; CI: confidence interval; DHCA: deep hypothermic circulatory arrest time; values between square brackets are unstandardized values of the regression coefficient, as the corresponding OR values are very high. Variables included in the stepwise model are deep hypothermic circulatory arrest time (min), RACHS category, chest kept open postop (yes versus no), gender, age (months), bypass time (≤70 min versus >70 min), and acute kidney injury.