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International Journal of Peptides
Volume 2010 (2010), Article ID 217267, 5 pages
Review Article

Ghrelin and Metabolic Surgery

1Department of Bariatric Surgery, Musgrove Park Hospital, Taunton, Somerset TA1 5DA, UK
2Imperial Weight Centre, Imperial College London, W6 8RF, UK

Received 16 September 2009; Revised 7 December 2009; Accepted 9 December 2009

Academic Editor: Alessandro Laviano

Copyright © 2010 Dimitrios J. Pournaras and Carel W. le Roux. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Metabolic surgery is the most effective treatment for morbid obesity. Ghrelin has been implicated to play a role in the success of these procedures. Furthermore, these operations have been used to study the gut-brain axis. This article explores this interaction, reviewing the available data on changes in ghrelin levels after different surgical procedures.