International Journal of Peptides

Update on Ghrelin


Publishing date
01 Apr 2010
Status
Published
Submission deadline
01 Oct 2009

Lead Editor

1Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Sakuragaoka, Kagoshima 890-8530, Japan

2Department of Neuroscience, McKnight Brain Institute of University of Florida, P.O. Box 100244 Gainesville, FL 32610-0244, USA

3ADEN Laboratory, Rouen University Medical School, 22 Boulevard Gambetta, 76183 Rouen, France

4Department of Clinical Medicine, University of Rome (Sapienza), Viale dell'Universita 37, 00185 Rome, Italy


Update on Ghrelin

Description

Ghrelin, a 28-amino acid peptide, was identified as the first endogenous ligand for growth hormone secretagogue receptor (GHSR) from the stomach. Ghrelin acts on GHSR to stimulate growth hormone (GH) release, which is distinct from its stimulation by hypothalamic GH-releasing hormone, and features a unique posttranslational modification of O-n–octanoylation at serine 3. The posttranslational modification of octanoylation is the first in peptide discovery history that appears to be essential for GH-releasing ability as well as for acyl ghrelin's regulation of food intake, adiposity, and insulin secretion.

The ghrelin peptides consist of acyl ghrelin, des-acyl ghrelin, and obestatin which are obtained from alternative splicing or from extensive posttranslational modification of preproghrelin. Very recently, the acyl-transferase responsible for ghrelin acylation, ghrelin O-acyltransferase (GOAT), was discovered. Acyl ghrelin, des-acyl ghrelin, and obestatin may be part of a system with multiple effector elements, and form the center of an integrated gut-brain-energy axis modulating appetite, digestive secretion and motility, and metabolism. The investigation of this peptide family makes it possible to penetrate the still undefined pathophysiology of eating and digestive diseases, and opens up new paradigms for drugs that can tackle multiple symptoms in various human disorders.

We invite authors to present original research articles as well as review articles that will stimulate the continuing efforts in defining the role of ghrelin family peptides in basic and clinical medicine. We are particularly interested in manuscripts that report translational research data, and reviews summarizing the results of latest clinical trials are welcomed. The topics to be covered include, but are not limited to:

  • Motilin-ghrelin family in the regulation of GI motility
  • Feeding and body weight regulation by ghrelin peptides
  • Growth hormone and other pituitary and pancreatic hormone secretion
  • Ghrelin peptides and behavior
  • Development of ghrelin agonists and antagonists
  • Application of ghrelin mimetics to anorexia and cachexia
  • Ghrelin antagonism and obesity/metabolic syndrome
  • Ghrelin peptides and immune function

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/ijpep/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2010
  • - Article ID 963501
  • - Editorial

Update on Ghrelin

Sergueï O. Fetissov | Alessandro Laviano | ... | Akio Inui
  • Special Issue
  • - Volume 2010
  • - Article ID 248948
  • - Review Article

Ghrelin in Diabetes and Metabolic Syndrome

Leena Pulkkinen | Olavi Ukkola | ... | Matti Uusitupa
  • Special Issue
  • - Volume 2010
  • - Article ID 275804
  • - Review Article

Differential Roles for Octanoylated and Decanoylated Ghrelins in Regulating Appetite and Metabolism

Sara E. Schwandt | Sarath C. Peddu | Larry G. Riley
  • Special Issue
  • - Volume 2010
  • - Article ID 864342
  • - Review Article

Metabolic and Cardiovascular Effects of Ghrelin

Manfredi Tesauro | Francesca Schinzari | ... | Carmine Cardillo
  • Special Issue
  • - Volume 2010
  • - Article ID 305192
  • - Review Article

Ghrelin, Des-Acyl Ghrelin, and Obestatin: Regulatory Roles on the Gastrointestinal Motility

Mineko Fujimiya | Akihiro Asakawa | ... | Akio Inui
  • Special Issue
  • - Volume 2010
  • - Article ID 945056
  • - Review Article

Ghrelin Cells in the Gastrointestinal Tract

Ichiro Sakata | Takafumi Sakai
  • Special Issue
  • - Volume 2010
  • - Article ID 158102
  • - Review Article

Ghrelin in Female and Male Reproduction

Joëlle Dupont | Virginie Maillard | ... | Pascal Froment
  • Special Issue
  • - Volume 2010
  • - Article ID 365416
  • - Research Article

Reconstruction-Dependent Recovery from Anorexia and Time-Related Recovery of Regulatory Ghrelin System in Gastrectomized Rats

Masaru Koizumi | Katsuya Dezaki | ... | Toshihiko Yada
  • Special Issue
  • - Volume 2010
  • - Article ID 616757
  • - Review Article

Ghrelin: Central Nervous System Sites of Action in Regulation of Energy Balance

Mark Fry | Alastair V. Ferguson
  • Special Issue
  • - Volume 2010
  • - Article ID 460549
  • - Review Article

Ghrelin's Roles in Stress, Mood, and Anxiety Regulation

Jen-Chieh Chuang | Jeffrey M. Zigman

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