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International Journal of Peptides
Volume 2010 (2010), Article ID 817457, 11 pages
Review Article

Interactions of Gastrointestinal Peptides: Ghrelin and Its Anorexigenic Antagonists

1Division Hepatology, Gastroenterology, and Endocrinology, Department of Medicine, Charité—Universitätsmedizin Berlin, Campus Virchow, 13353 Berlin, Germany
2Department of Medicine, Institute of Neurogastroenterology, Martin-Luther-Hospital, 14193 Berlin, Germany
3Division Psychosomatic Medicine and Psychotherapy, Department of Medicine, Charité—Universitätsmedizin Berlin, Campus Mitte, 10117 Berlin, Germany

Received 13 August 2009; Revised 13 October 2009; Accepted 19 October 2009

Academic Editor: Akio Inui

Copyright © 2010 Anna-Sophia Wisser et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Food intake behaviour and energy homeostasis are strongly regulated by a complex system of humoral factors and nerval structures constituting the brain-gut-axis. To date the only known peripherally produced and centrally acting peptide that stimulates food intake is ghrelin, which is mainly synthesized in the stomach. Recent data indicate that the orexigenic effect of ghrelin might be influenced by other gastrointestinal peptides such as cholecystokinin (CCK), bombesin, desacyl ghrelin, peptide YY (PYY), as well as glucagon-like peptide (GLP). Therefore, we will review on the interactions of ghrelin with several gastrointestinal factors known to be involved in appetite regulation in order to elucidate the interdependency of peripheral orexigenic and anorexigenic peptides in the control of appetite.