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International Journal of Proteomics
Volume 2011 (2011), Article ID 343582, 9 pages
Review Article

Protein Biomarkers for the Early Detection of Breast Cancer

1Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48109-5656, USA
2The Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109-5656, USA

Received 24 May 2011; Accepted 23 June 2011

Academic Editor: Tadashi Kondo

Copyright © 2011 David E. Misek and Evelyn H. Kim. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Advances in breast cancer control will be greatly aided by early detection so as to diagnose and treat breast cancer in its preinvasive state prior to metastasis. For breast cancer, the second leading cause of cancer-related death among women in the United States, early detection does allow for increased treatment options, including surgical resection, with a corresponding better patient response. Unfortunately, however, many patients' tumors are diagnosed following metastasis, thus making it more difficult to successfully treat the malignancy. There are, at present, no existing validated plasma/serum biomarkers for breast cancer. Only a few biomarkers (such as HER-2/neu, estrogen receptor, and progesterone receptor) have utility for diagnosis and prognosis. Thus, there is a great need for new biomarkers for breast cancer. This paper will focus on the identification of new serum protein biomarkers with utility for the early detection of breast cancer.