Proteomic Approach to Evaluate Mechanisms That Contribute to Food Allergenicity: Comparative 2D-DIGE Analysis of Radioallergosorbent Test Positive and Negative Patients

Table 3

List of the most significant gene ontology (GO) processes associated with the biological network shown in Figure 6 as determined by MetaCore analysis along with the corresponding 𝑃 values which indicates that the key protein identified by proteomic analysis are associated with the listed biological processes in a prioritized manner.

Number	Biological process	% involvement in the biological process	𝑃 value
1	Positive regulation of immune system process	35.23	2.280 𝑒−50
2	MyD88-independent toll-like receptor signaling pathway	19.32	2.516 𝑒−49
3	Toll-like receptor 3 signaling pathway	19.32	4.103 𝑒−49
4	Toll-like receptor signaling pathway	19.89	5.703 𝑒−48
5	Signal transmission via phosphorylation event	32.95	8.113 𝑒−48
6	Intracellular protein kinase cascade	32.95	8.113 𝑒−48
7	Positive regulation of response to stimulus	33.52	3.663 𝑒−47
8	Pattern recognition receptor signaling pathway	19.89	8.743 𝑒−47
9	Activation of innate immune response	19.89	2.639 𝑒−46
10	Innate immune response-activating signal transduction	19.89	2.639 𝑒−46
11	Positive regulation of biological process	63.64	4.550 𝑒−46
12	Positive regulation of defense response	24.43	4.898 𝑒−46