Scaffolds for Growth Factor Delivery as Applied to Bone Tissue Engineering
Normalized release profiles of 125I-BMP-2 from the four different implants (% of the initial loading): (a) in vitro (b) in vivo in a rat subcutaneous implantation model. (c) New bone formation after 6 and 12 weeks of implantation. Image reconstruction was derived from μCT scans using standardized thresholds. (d) Average volumes of newly formed bone in the four different scaffolds after 6 and 12 weeks of implantation (left axis), and normalized to an 8 mm long, 3.5 mm diameter cylindrical scaffold (right axis). Significant difference relative to (a) all other implants, (b) Mps/gelatin implant, and (c) gelatin implant at the same time point. (d) Significant increase in bone formation relative to the previous time point .