Review Article
Scaffolds for Growth Factor Delivery as Applied to Bone Tissue Engineering
Table 2
Summary of the growth factor, polymer used, and size of microspheres studies recently released.
| Polymer | Growth factor | Formation technique | Microsphere size | Reference |
| PEG-PLGA diblock | BMP-2 | w/o/w | 37–67 μm | [48] | PLGA/PLGA-PEG-PLGA | BMP-2 | w/o/w | 67–127 μm | [61] | Gelatine cross-linked with genipin | BMP-2 | w/o | undisclosed | [72] | Gelatine cross-linked with genipin | BMP-2 | w/o | 2–6 μm
| [52] | PLGA | BMP-2 | w/o/w | 100–150 μm | [63] | PLGA | BMP-2 | w/o/w | Average of 50 μm | [113] | PLGA | BMP-2 | w/o/w | Undisclosed | [114] | PLGA | VEGF | w/o/w | Undisclosed | [115] | PLGA | VEGF | w/o/w | 20–53 μm | [116] | PLGA | VEGF + FGF-2 | w/o/w | undisclosed (fused microsphere bridge) | [108] | PLGA | VEGF + FGF-2 | s/o/w | Undisclosed | [67] | Alginate | VEGF | w/o/w | 300–400 μm | [47] | PEG-CAM-PEG | VEGF + BMP-2 | s/o/w | 5–30 μm | [117] | PLGA | VEGF, FGF-2, VEGF + FGF-2 | w/o/w | ~20–100 μm | [65] | PLGA | PDGF | w/o/w | 7–31 μm | [118] microsphere formation in [119] | PLGA | BMP-2 + TGFβ | Ultrasound o/w | Undisclosed (fused microsphere bridge) | [120] | PLGA | LTB4 | w/o/w | 5–10 μm | [107] | Hyaluronic acid | BMP-2 | w/o/w | 710 nm–1.7 μm | [121] | PLGA | BMP-2 | w/o/w | 120–470 μm | [122] | P(TMC-CL)2-PEG | BMP-6 + TGFβ3 | Electrospraying o/w | ~65-80 μm | [51] | Gelatine cross-linked with glutaraldehyde | VEGF + BMP-2 | w/o | 50–100 μm | [70] | Silk fibroin | BMP-2 BMP-9 or BMP-14 | Nanoprecipitation | 2.4–3 μm | [58] | PLLA | BMP-2 | w/o | 35–55 nm | [104] |
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