Application of Biodegradable Polyhydroxyalkanoates as Surgical Films for Ventral Hernia Repair in Mice

Figure 5

Tissue reaction to the P3HB and P3HBV films at the hernia repair site. (a) Histological images of P3HB, P3HBV, and polypropylene (PP) films and surrounding tissue at different time points after hernia repair. The slides were stained using the H&E and immunohistochemistry methods for CD68-positive macrophage. S = skin; P = peritoneal cavity. The scale bars represent different magnification levels indicated below the bottom row. (b) The thickness of tissue below the film was calculated using Image J software. The bars represent the mean values of 6 mice, and the error bars represent the standard deviation. Statistically significant difference between the PP and P3HB groups. ^#Statistically significant difference between the P3HBV and P3HB groups.

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