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International Journal of Polymer Science
Volume 2016, Article ID 2634104, 8 pages
http://dx.doi.org/10.1155/2016/2634104
Research Article

Deposition of Ibuprofen Crystals on Hydroxypropyl Cellulose/Polyacrylamide Gel: Experimental and Mathematic Modeling Releasing

1División de Estudios de Posgrado e Investigación, Instituto Tecnológico de Ciudad Madero, Juventino Rosas y Jesús Urueta s/n, Colonia Los Mangos, 89318 Ciudad Madero, TAMPS, Mexico
2CONACyT-Instituto de Investigaciones Eléctricas, Reforma 113, Colonia Palmira, Cuernavaca 62490, MOR, Mexico
3Departamento de Ciencias Básicas del Instituto Tecnológico de Ciudad Madero, Juventino Rosas y Jesús Urueta s/n, Colonia Los Mangos, 89318 Ciudad Madero, TAMPS, Mexico

Received 12 May 2016; Revised 28 August 2016; Accepted 6 September 2016

Academic Editor: Ming-Guo Ma

Copyright © 2016 Claudia Alicia Castillo-Miranda et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The crystallization of nonsteroidal anti-inflammatory drug [2-(4-isobutyl-phenyl) propionic acid] ibuprofen (IBP) on a hydroxypropyl cellulose (HPC) and polyacrylamide (PAAm) gel was studied as well as the release kinetics of the drug. The IBP was crystallized on the gel surface of HPC/PAAm. It had a prismatic shape and the growth was made in an aqueous medium; the crystallinity grade of the gels HPC/PAAm and HPC/PAAm-IBU increased to 68% and to 58%, respectively. The release of IBP is performed by two means: by a non-Fickian diffusion process and by relaxation of the chains of the gel; without regard to temperature and the diffusion media, this correlates with the lower critical solution temperature (LCST) of the proposed gel. This polymer matrix provides an option for releasing nonsteroidal anti-inflammatory drugs in a temperature range of 35–39°C. Korsmeyer and Peppas mathematical model was simulated for data releases, statistically significant at 95% confidence level.