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International Journal of Polymer Science
Volume 2016, Article ID 4235832, 7 pages
Research Article

Development of Bioadhesive Microspheres for Oral Bioavailability Enhancement of Berberine Hydrochloride

1Department of Pharmaceutical Sciences, Zibo Vocational Institute, Zibo, Shandong 255314, China
2Zibo Institute for Food and Drug Control, Zibo, Shandong 255086, China

Received 22 May 2016; Accepted 20 September 2016

Academic Editor: Ruilong Sheng

Copyright © 2016 Ye Zhang and Hongming Liu. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The objective of this study was to innovatively prepare chitosan-coated alginate/gelatin BBH loaded microspheres and evaluate their pharmaceutical characteristics and pharmacokinetics. The bioadhesive microspheres were prepared using an emulsification technique. Three batches of microspheres were formed and their stability was evaluated. BBH loaded microspheres were almost spherical with shallow elevation on surfaces. The mean particle size of microspheres was 368.2 μm, drug loading was %, and in situ bioadhesion percentage was and they achieved a sustained release with 71.29% for 8 hours in vitro. Pharmacokinetic studies in rats indicated that the bioavailability of BBH microspheres was enhanced about 1.5-fold as compared with commercial tablets. BBH microspheres exhibited a sustained-release profile over 48 h. Thus, chitosan-coated alginate/gelatin BBH loaded microspheres which combined the advantages of alginate/gelatin microspheres and chitosan may be used as a sustained delivery system for BBH to treat duodenal and benign gastric ulcers.