Table of Contents Author Guidelines Submit a Manuscript
International Journal of Polymer Science
Volume 2016, Article ID 4235832, 7 pages
http://dx.doi.org/10.1155/2016/4235832
Research Article

Development of Bioadhesive Microspheres for Oral Bioavailability Enhancement of Berberine Hydrochloride

1Department of Pharmaceutical Sciences, Zibo Vocational Institute, Zibo, Shandong 255314, China
2Zibo Institute for Food and Drug Control, Zibo, Shandong 255086, China

Received 22 May 2016; Accepted 20 September 2016

Academic Editor: Ruilong Sheng

Copyright © 2016 Ye Zhang and Hongming Liu. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. Y. S. Lee, W. S. Kim, K. H. Kim et al., “Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states,” Diabetes, vol. 55, no. 8, pp. 2256–2264, 2006. View at Publisher · View at Google Scholar · View at Scopus
  2. N. Shen, X. Li, T. Zhou et al., “Shensong Yangxin Capsule prevents diabetic myocardial fibrosis by inhibiting TGF-β1/Smad signaling,” Journal of Ethnopharmacology, vol. 157, pp. 161–170, 2014. View at Publisher · View at Google Scholar · View at Scopus
  3. S. K. Kulkarni and A. Dhir, “On the mechanism of antidepressant-like action of berberine chloride,” European Journal of Pharmacology, vol. 589, no. 1–3, pp. 163–172, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. S. K. Kulkarni and A. Dhir, “Possible involvement of L-arginine-nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) signaling pathway in the antidepressant activity of berberine chloride,” European Journal of Pharmacology, vol. 569, no. 1-2, pp. 77–83, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. W.-H. Peng, K.-L. Lo, Y.-H. Lee, T.-H. Hung, and Y.-C. Lin, “Berberine produces antidepressant-like effects in the forced swim test and in the tail suspension test in mice,” Life Sciences, vol. 81, no. 11, pp. 933–938, 2007. View at Publisher · View at Google Scholar · View at Scopus
  6. W. Kong, J. Wei, P. Abidi et al., “Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins,” Nature Medicine, vol. 10, no. 12, pp. 1344–1351, 2004. View at Publisher · View at Google Scholar · View at Scopus
  7. G.-Y. Pan, G.-J. Wang, X.-D. Liu, J. P. Fawcett, and Y.-Y. Xie, “The involvement of P-glycoprotein in berberine absorption,” Pharmacology & Toxicology, vol. 91, no. 4, pp. 193–197, 2002. View at Publisher · View at Google Scholar · View at Scopus
  8. H.-J. Maeng, H.-J. Yoo, I.-W. Kim, I.-S. Song, S.-J. Chung, and C.-K. Shim, “P-glycoprotein-mediated transport of berberine across Caco-2 cell monolayers,” Journal of Pharmaceutical Sciences, vol. 91, no. 12, pp. 2614–2621, 2002. View at Publisher · View at Google Scholar · View at Scopus
  9. Y. Zhang, Y.-L. Cui, L.-N. Gao, and H.-L. Jiang, “Effects of β-cyclodextrin on the intestinal absorption of berberine hydrochloride, a P-glycoprotein substrate,” International Journal of Biological Macromolecules, vol. 59, pp. 363–371, 2013. View at Publisher · View at Google Scholar · View at Scopus
  10. J.-X. Zhu, D. Tang, L. Feng et al., “Development of self-microemulsifying drug delivery system for oral bioavailability enhancement of berberine hydrochloride,” Drug Development and Industrial Pharmacy, vol. 39, no. 3, pp. 499–506, 2013. View at Publisher · View at Google Scholar · View at Scopus
  11. N. Foster and B. H. Hirst, “Exploiting receptor biology for oral vaccination with biodegradable particulates,” Advanced Drug Delivery Reviews, vol. 57, no. 3, pp. 431–450, 2005. View at Publisher · View at Google Scholar · View at Scopus
  12. L. Illum, I. Jabbal-Gill, M. Hinchcliffe, A. N. Fisher, and S. S. Davis, “Chitosan as a novel nasal delivery system for vaccines,” Advanced Drug Delivery Reviews, vol. 51, no. 1–3, pp. 81–96, 2001. View at Publisher · View at Google Scholar · View at Scopus
  13. X. Peng, L. Zhang, and J. F. Kennedy, “Release behavior of microspheres from cross-linked N-methylated chitosan encapsulated ofloxacin,” Carbohydrate Polymers, vol. 65, no. 3, pp. 288–295, 2006. View at Publisher · View at Google Scholar · View at Scopus
  14. L.-Y. Wang, Y.-H. Gu, Q.-Z. Zhou, G.-H. Ma, Y.-H. Wan, and Z.-G. Su, “Preparation and characterization of uniform-sized chitosan microspheres containing insulin by membrane emulsification and a two-step solidification process,” Colloids and Surfaces B: Biointerfaces, vol. 50, no. 2, pp. 126–135, 2006. View at Publisher · View at Google Scholar · View at Scopus
  15. M. N. Uddin, N. J. Patel, T. Bhowmik et al., “Enhanced bioavailability of orally administered antisense oligonucleotide to nuclear factor kappa B mRNA after microencapsulation with albumin,” Journal of Drug Targeting, vol. 21, no. 5, pp. 450–457, 2013. View at Publisher · View at Google Scholar · View at Scopus
  16. L.-D. Hu, Q.-B. Xing, C. Shang et al., “Preparation of rosiglitazone maleate sustained-release floating microspheres for improved bioavailability,” Pharmazie, vol. 65, no. 7, pp. 477–480, 2010. View at Publisher · View at Google Scholar · View at Scopus
  17. M. D. Blanco, M. V. Bernardo, R. L. Sastre, R. Olmo, E. Muñiz, and J. M. Teijón, “Preparation of bupivacaine-loaded poly(ε-caprolactone) microspheres by spray drying: drug release studies and biocompatibility,” European Journal of Pharmaceutics and Biopharmaceutics, vol. 55, no. 2, pp. 229–236, 2003. View at Publisher · View at Google Scholar · View at Scopus
  18. R. K. Jha, S. Tiwari, and B. Mishra, “Bioadhesive microspheres for bioavailability enhancement of raloxifene hydrochloride: formulation and pharmacokinetic evaluation,” AAPS PharmSciTech, vol. 12, no. 2, pp. 650–657, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. A. Gifani, M. Taghizadeh, A. A. Seifkordi, and M. Ardjmand, “Preparation and investigation the release behaviour of wax microspheres loaded with salicylic acid,” Journal of Microencapsulation, vol. 26, no. 6, pp. 485–492, 2009. View at Publisher · View at Google Scholar · View at Scopus
  20. S. G. Gayakwad, N. K. Bejugam, N. Akhavein, N. A. Uddin, C. E. Oettinger, and M. J. D'Souza, “Formulation and in vitro characterization of spray-dried antisense oligonucleotide to NF-kappaB encapsulated albumin microspheres,” Journal of Microencapsulation, vol. 26, no. 8, pp. 692–700, 2009. View at Publisher · View at Google Scholar · View at Scopus
  21. F. Yang, F.-L. Song, Y.-F. Pan et al., “Preparation and characteristics of interferon-alpha poly(lactic-co-glycolic acid) microspheres,” Journal of Microencapsulation, vol. 27, no. 2, pp. 133–141, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. S. S. Xu, J. Wu, and W. Jiang, “Synthesis and characterisation of a pH-sensitive magnetic nanocomposite for controlled delivery of doxorubicin,” Journal of Microencapsulation, vol. 32, no. 6, pp. 533–537, 2015. View at Publisher · View at Google Scholar · View at Scopus
  23. E. Başaran, E. Yenilmez, M. S. Berkman, G. Büyükköroğlu, and Y. Yazan, “Chitosan nanoparticles for ocular delivery of cyclosporine A,” Journal of Microencapsulation, vol. 31, no. 1, pp. 49–57, 2014. View at Publisher · View at Google Scholar · View at Scopus
  24. N. Yüksel, A. Aydmli, Y. Özalp, and N. Özdemir, “Evaluation and preparation of controlled release lipid micropheres of sulphamethizole by a congealable disperse phase encapsulation method,” Acta Poloniae Pharmaceutica—Drug Research, vol. 57, no. 3, pp. 187–192, 2000. View at Google Scholar · View at Scopus
  25. T. Chandy and C. P. Sharma, “Chitosan—as a biomaterial,” Biomaterials, Artificial Cells and Artificial Organs, vol. 18, no. 1, pp. 1–24, 1990. View at Publisher · View at Google Scholar · View at Scopus
  26. W.-M. Hou, S. Miyazaki, M. Takada, and T. Komai, “Sustained release of indomethacin from chitosan granules,” Chemical & Pharmaceutical Bulletin, vol. 33, no. 9, pp. 3986–3992, 1985. View at Publisher · View at Google Scholar · View at Scopus
  27. H.-W. Sung, D.-M. Huang, W.-H. Chang, R.-N. Huang, and J.-C. Hsu, “Evaluation of gelatin hydrogel crosslinked with various crosslinking agents as bioadhesives: in vitro study,” Journal of Biomedical Materials Research, vol. 46, no. 4, pp. 520–530, 1999. View at Publisher · View at Google Scholar · View at Scopus
  28. X. Z. Shu and K. J. Zhu, “A novel approach to prepare tripolyphosphate/chitosan complex beads for controlled release drug delivery,” International Journal of Pharmaceutics, vol. 201, no. 1, pp. 51–58, 2000. View at Publisher · View at Google Scholar · View at Scopus
  29. K. V. R. Rao and P. Buri, “A novel in situ method to test polymers and coated microparticles for bioadhesion,” International Journal of Pharmaceutics, vol. 52, no. 3, pp. 265–270, 1989. View at Publisher · View at Google Scholar · View at Scopus
  30. F. Lagarce, P. Renaud, N. Faisant et al., “Baclofen-loaded microspheres: preparation and efficacy testing in a new rabbit model,” European Journal of Pharmaceutics and Biopharmaceutics, vol. 59, no. 3, pp. 449–459, 2005. View at Publisher · View at Google Scholar · View at Scopus
  31. F. T. Meng, G. H. Ma, W. Qiu, and Z. G. Su, “W/O/W double emulsion technique using ethyl acetate as organic solvent: effects of its diffusion rate on the characteristics of microparticles,” Journal of Controlled Release, vol. 91, no. 3, pp. 407–416, 2003. View at Publisher · View at Google Scholar · View at Scopus
  32. H. Jeffery, S. S. Davis, and D. T. O'Hagan, “The preparation and characterization of poly(lactide-co-glycolide) microparticles. II. The entrapment of a model protein using a (water-in-oil)-in-water emulsion solvent evaporation technique,” Pharmaceutical Research, vol. 10, no. 3, pp. 362–368, 1993. View at Publisher · View at Google Scholar · View at Scopus
  33. Q.-S. Wang, Y.-L. Cui, Y. Zhang, Y.-B. Zhang, and X.-M. Gao, “Preparation and evaluation of chitosan-coated alginate/gelatin sustained releasing microspheres containing berberine hydrochloride in vitro,” in Proceedings of the 3rd International Conference on Bioinformatics and Biomedical Engineering (iCBBE '09), pp. 1–4, IEEE, Beijing, China, June 2009. View at Publisher · View at Google Scholar · View at Scopus
  34. J. Herrmann and R. Bodmeier, “Biodegradable, somatostatin acetate containing microspheres prepared by various aqueous and non-aqueous solvent evaporation methods,” European Journal of Pharmaceutics and Biopharmaceutics, vol. 45, no. 1, pp. 75–82, 1998. View at Publisher · View at Google Scholar · View at Scopus
  35. Y.-Y. Yang, H.-H. Chia, and T.-S. Chung, “Effect of preparation temperature on the characteristics and release profiles of PLGA microspheres containing protein fabricated by double-emulsion solvent extraction/evaporation method,” Journal of Controlled Release, vol. 69, no. 1, pp. 81–96, 2000. View at Publisher · View at Google Scholar · View at Scopus
  36. P. He, S. S. Davis, and L. Illum, “Chitosan microspheres prepared by spray drying,” International Journal of Pharmaceutics, vol. 187, no. 1, pp. 53–65, 1999. View at Publisher · View at Google Scholar · View at Scopus
  37. A. Gèze, M. C. Venier-Julienne, D. Mathieu, R. Filmon, R. Phan-Tan-Luu, and J. P. Benoit, “Development of 5-iodo-2′-deoxyuridine milling process to reduce initial burst release from PLGA microparticles,” International Journal of Pharmaceutics, vol. 178, no. 2, pp. 257–268, 1999. View at Publisher · View at Google Scholar · View at Scopus
  38. G. Spenlehauer, M. Vert, J.-P. Benoît, F. Chabot, and M. Veillard, “Biodegradable cisplatiim microspheres prepared by the solvent evaporation method: morphology and release characteristics,” Journal of Controlled Release, vol. 7, no. 3, pp. 217–229, 1988. View at Publisher · View at Google Scholar · View at Scopus