Table 4: List of the pharmaceutical products based on ALG.

ProductMain ingredientsDescriptionIndications

Oral administration
Gastrotuss® baby syrup [22, 23]Magnesium alginate, simethicone, fructose, xanthan gum, honey, D-panthenol, fluid extracts of Althaea officinalis, Papaver rhoeas, zinc oxide, sodium bicarbonate, sodium hydroxideCreates a mechanical barrier between the stomach and the esophagus which prevents the reflux, recurrent symptoms of respiratory, choking, dysphagia, heartburn, belching, irritability; accelerates gastric movement, regenerates mucous membranes of the esophagus and ensures its protectionChildren and infants from the first days of life reflux treatment
Algicid® suspension/tablets [24]500 mg sodium alginate, 100 mg potassium bicarbonate per 5 ml/per 1 tabletAdult reflux treatment
Gaviscon Double Action Liquid® [25]250 mg sodium alginate, 106.5 mg sodium bicarbonate, and 162.5 mg calcium carbonate per 5 ml
Gaviscon Double Action tablets® [26]250 mg sodium alginate, 106.5 mg sodium bicarbonate, and 187.5 mg calcium carbonate per tablet

Dermal application
Flaminal Forte® gel [27]Hydrated alginates polymers in a polyethylene glycol (PEG) matrix with a biologic enzyme system based on glucose oxidase and lactoperoxidase stabilized by guaiacolDissolution of dry scab and necrotic material, absorption of lysed material and bacteria by alginates in hydrated formLeg and diabetic ulcers, pressure sores, complex grazes, burns, oncology and wounds dermatosurgery
Purilon Gel® gel [28]Carboxymethylcellulose, calcium alginateProvides moist environment at wound surfaceDry and sloughy necrotic wounds, pressure and venous ulcers, second-degree burns, cuts, abrasions and skin tear, noninfected diabetic foot ulcers
Saf-Gel® gel [29]Carbomer, propylene glycol sodium/calcium alginate
Hyalogran® dressing [30]Ester of hyaluronic acid (HA) and sodium alginateExudate absorbs and transforms to soft gel; removes necrotic tissueVariety of exuding wounds including leg ulcers, pressure sores, ischemic and diabetic wounds, particularly those which are covered with slough and necrotic tissue or areas that are difficult to dress
SeaSorb® dressing [31]Calcium alginateCreates moist environment at wound surface, conversion soft fibres to wet gelHeavily exuding wounds including leg and pressure ulcers, diabetic ulcers and second-degree burns, cavity wounds
Tromboguard® dressing [32]Two-layer dressing built from hydrophilic polyurethane sponges and biologically active layer containing chitosan, sodium alginate, calcium alginate, and silver cationsStrong haemostatic and antibacterial activityControl of bleeding traumatic and postoperative wounds
Fibracol Plus® dressing [32]90% collagen and 10% calcium alginateProvides moist environment at wound surface, tissue granulation, epithelialisation, and healingExuding wounds including: full-thickness and partial-thickness wounds; pressure ulcers; venous ulcers; ulcers caused by mixed vascular etiologies; diabetic ulcers; second-degree burns
Algivon® dressing [33]Calcium alginate dressing impregnated with Manuka honeyBinds of exudate, regenerationSloughy, necrotic, and malodorous wounds
Guardix-SG® [34, 35]Sodium alginate, poloxamer, calcium chlorideCreates thermosensitive viscous gel in contact with body temperature and forms mechanical barrier separates injured tissuesIn spine and thyroid surgeries to reduction of the incidence postoperative adhesions

Rectal administration
Natalsid® suppositories [36]Sodium alginateAnti-inflammatory local actionChronic haemorrhoids, proctosigmoiditis, and chronic anal fissures after surgical interventions in the area of the rectum

Periodontal application
Progenix putty®, Progenix plus® injection [37]Demineralised bone matrix in type-1 bovine collagen and sodium alginateRegeneration, complementation of bone losses; periodontal diseasesBony voids or gaps of the skeletal system
Emdogain® gel [3840]Enamel matrix derivative (EMD), propylene glycol alginateRegeneration, periodontal diseases, paradontosis1-, 2-, and 3-wall intrabony defects, class II mandibular furcation defects with minimal interproximal bone loss, recession defects

Arthroscopic application
ChondroArt 3D™ injection [41]Autologous chondrocytes situated on a hydrogel scaffold built from connection of alginate and agaroseIncrease production and growth of cartilageDegenerative diseases of joints and backbones (osteoarthrosis, osteochondrosis)