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| Product | Main ingredients | Description | Indications |
|
| Oral administration |
| Gastrotuss® baby syrup [22, 23] | Magnesium alginate, simethicone, fructose, xanthan gum, honey, D-panthenol, fluid extracts of Althaea officinalis, Papaver rhoeas, zinc oxide, sodium bicarbonate, sodium hydroxide | Creates a mechanical barrier between the stomach and the esophagus which prevents the reflux, recurrent symptoms of respiratory, choking, dysphagia, heartburn, belching, irritability; accelerates gastric movement, regenerates mucous membranes of the esophagus and ensures its protection | Children and infants from the first days of life reflux treatment |
| Algicid® suspension/tablets [24] | 500 mg sodium alginate, 100 mg potassium bicarbonate per 5 ml/per 1 tablet | Adult reflux treatment |
| Gaviscon Double Action Liquid® [25] | 250 mg sodium alginate, 106.5 mg sodium bicarbonate, and 162.5 mg calcium carbonate per 5 ml |
| Gaviscon Double Action tablets® [26] | 250 mg sodium alginate, 106.5 mg sodium bicarbonate, and 187.5 mg calcium carbonate per tablet |
|
| Dermal application |
| Flaminal Forte® gel [27] | Hydrated alginates polymers in a polyethylene glycol (PEG) matrix with a biologic enzyme system based on glucose oxidase and lactoperoxidase stabilized by guaiacol | Dissolution of dry scab and necrotic material, absorption of lysed material and bacteria by alginates in hydrated form | Leg and diabetic ulcers, pressure sores, complex grazes, burns, oncology and wounds dermatosurgery |
| Purilon Gel® gel [28] | Carboxymethylcellulose, calcium alginate | Provides moist environment at wound surface | Dry and sloughy necrotic wounds, pressure and venous ulcers, second-degree burns, cuts, abrasions and skin tear, noninfected diabetic foot ulcers |
| Saf-Gel® gel [29] | Carbomer, propylene glycol sodium/calcium alginate |
| Hyalogran® dressing [30] | Ester of hyaluronic acid (HA) and sodium alginate | Exudate absorbs and transforms to soft gel; removes necrotic tissue | Variety of exuding wounds including leg ulcers, pressure sores, ischemic and diabetic wounds, particularly those which are covered with slough and necrotic tissue or areas that are difficult to dress |
| SeaSorb® dressing [31] | Calcium alginate | Creates moist environment at wound surface, conversion soft fibres to wet gel | Heavily exuding wounds including leg and pressure ulcers, diabetic ulcers and second-degree burns, cavity wounds |
| Tromboguard® dressing [32] | Two-layer dressing built from hydrophilic polyurethane sponges and biologically active layer containing chitosan, sodium alginate, calcium alginate, and silver cations | Strong haemostatic and antibacterial activity | Control of bleeding traumatic and postoperative wounds |
| Fibracol Plus® dressing [32] | 90% collagen and 10% calcium alginate | Provides moist environment at wound surface, tissue granulation, epithelialisation, and healing | Exuding wounds including: full-thickness and partial-thickness wounds; pressure ulcers; venous ulcers; ulcers caused by mixed vascular etiologies; diabetic ulcers; second-degree burns |
| Algivon® dressing [33] | Calcium alginate dressing impregnated with Manuka honey | Binds of exudate, regeneration | Sloughy, necrotic, and malodorous wounds |
| Guardix-SG® [34, 35] | Sodium alginate, poloxamer, calcium chloride | Creates thermosensitive viscous gel in contact with body temperature and forms mechanical barrier separates injured tissues | In spine and thyroid surgeries to reduction of the incidence postoperative adhesions |
|
| Rectal administration |
| Natalsid® suppositories [36] | Sodium alginate | Anti-inflammatory local action | Chronic haemorrhoids, proctosigmoiditis, and chronic anal fissures after surgical interventions in the area of the rectum |
|
| Periodontal application |
| Progenix putty®, Progenix plus® injection [37] | Demineralised bone matrix in type-1 bovine collagen and sodium alginate | Regeneration, complementation of bone losses; periodontal diseases | Bony voids or gaps of the skeletal system |
| Emdogain® gel [38–40] | Enamel matrix derivative (EMD), propylene glycol alginate | Regeneration, periodontal diseases, paradontosis | 1-, 2-, and 3-wall intrabony defects, class II mandibular furcation defects with minimal interproximal bone loss, recession defects |
|
| Arthroscopic application |
| ChondroArt 3D™ injection [41] | Autologous chondrocytes situated on a hydrogel scaffold built from connection of alginate and agarose | Increase production and growth of cartilage | Degenerative diseases of joints and backbones (osteoarthrosis, osteochondrosis) |
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