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International Journal of Polymer Science
Volume 2016 (2016), Article ID 8082014, 9 pages
http://dx.doi.org/10.1155/2016/8082014
Research Article

Synthesis, Properties, and In Vitro Hydrolytic Degradation of Poly(d,l-lactide-co-glycolide-co-ε-caprolactone)

1Department of Sports Medicine and Joint Surgery, The First Affiliated Hospital of China Medical University, Shenyang 110001, China
2Department of Orthopaedics, The Central Hospital Affiliated to Shenyang Medical College, Shenyang 110024, China
3Department of Sports Medicine and Joint Surgery, The People’s Hospital of Liaoning Province, Shenyang 110015, China

Received 12 January 2016; Revised 3 April 2016; Accepted 14 April 2016

Academic Editor: Matthias Schnabelrauch

Copyright © 2016 Yixiu Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Random copolymers of poly(d,l-lactide-co-glycolide-co-ε-caprolactone) (PLGC) were synthesized by the ring-opening polymerization of d,l-lactide (DLLA), glycolide (GA), and ε-caprolactone (CL). The effects of CL on the copolymers were evaluated to prepare suitable copolymers with controlled properties. Our results showed that the CL content significantly influenced the thermal and mechanical properties of the copolymers and that the CL content in compositions could be altered to control properties of random copolymers. The in vitro hydrolytic degradation of the resulting implants showed that the degradation rate of PLGC was lower than that of PLGA, which could markedly reduce acidic degradation products. Finally, we demonstrated that higher CL contents in compositions slowed degradation rates.