Influence of Sodium Alginate on Hypoglycemic Activity of Metformin Hydrochloride in the Microspheres Obtained by the Spray Drying

Table 4

In vitro glucose uptake by yeast cells incubated with microspheres placebo, microspheres F6, and metformin hydrochloride (MF).

	Concentration of glucose (mM) remaining in the medium
	5 mM glucose	10 mM glucose	20 mM glucose
Control	3.79 ± 1.67	7.48 ± 0.72	14.72 ± 1.32
Microspheres placebo	4.56 ± 0.49	9.01 ± 1.61	17.84 ± 2.86
Microspheres F6	1.65 ± 2.79	3.13 ± 1.69	6.51 ± 1.01
MF	1.22 ± 0.18	1.50 ± 0.23	3.91 ± 0.69

Suspension of Saccharomyces cerevisiae cells in glucose solution; MF was used in an amount (10 mg) corresponding to its loading in microspheres formulation F6.