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International Journal of Polymer Science
Volume 2017, Article ID 3486384, 8 pages
Research Article

Influence of Hydrophilic Polymers on the Factor in Weibull Equation Applied to the Release Kinetics of a Biologically Active Complex of Aesculus hippocastanum

Department of Physical Chemistry, Faculty of Pharmacy, Wroclaw Medical University, ul. Borowska 211A, 50-556 Wroclaw, Poland

Correspondence should be addressed to Witold Musiał; moc.liamg@laisum.dlotiw

Received 27 October 2016; Accepted 26 December 2016; Published 29 January 2017

Academic Editor: Chao Lin

Copyright © 2017 Justyna Kobryń et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Triterpenoid saponins complex of biological origin, escin, exhibits significant clinical activity in chronic venous insufficiency, skin inflammation, epidermal abrasions, allergic dermatitis, and acute impact injuries, especially in topical application. The aim of the study is the comparison of various hydrogel formulations, as carriers for a horse chestnut seed extract (EH). Methylcellulose (MC), two polyacrylic acid derivatives (PA1 and PA2), and polyacrylate crosspolymer 11 (PC-11) were employed. The release rates of EH were examined and a comparison with the Weibull model equation was performed. Application of MC as the carrier in the hydrogel preparation resulted in fast release rate of EH, whereas in the case of the hydrogel composed with PC-11 the release was rather prolonged. Applied Weibull function adhered best to the experimental data. Due to the evaluated shape parameter β, in the Weibull equation, the systems under study released the active compound according to the Fickian diffusion.