Influence of Hydrophilic Polymers on the Factor in Weibull Equation Applied to the Release Kinetics of a Biologically Active Complex of Aesculus hippocastanum

Table 3

The parameters determined in the course of release kinetics evaluation of gel formulations P1, P2, P3, and P4.

Parameter	Kinetics model								BF
	Zero-order		1st-order		2nd-order		Weibull
	%⋅min^−1	SD		SD	min^−1⋅%^−1	SD	β	SD
	Formulation type: P1 (MC formulation)
Constant									II
	0.96380	0.01246	0.98490	0.00791	0.99500	0.00216	0.99584	0.00327
	Formulation type: P2 (PA1 formulation)
Constant									II
	0.95712	0.00802	0.97493	0.00657	0.98776	0.00464	0.99801	0.00063
	Formulation type: P3 (PC-11 formulation)
Constant									II
	0.95224	0.00464	0.96941	0.00356	0.98286	0.00256	0.99632	0.00129
	Formulation type: P4 (PA2, reference formulation)
Constant									II
	0.97479	0.00131	0.99155	0.00110	0.99840	0.00027	0.99134	0.00516

represents release rates for respective models: zero-order kinetics (), 1st-order kinetics (), and 2nd-order kinetics (); , a shape parameter in Weibull model; , correlation coefficient for the regression fit describing the course of the release as the first-order process; MC, methylcellulose; PA1, polyacrylic acid derivative Carbopol 980P NF; PC-11, modified polyacrylic acid; PA2, polyacrylic acid derivative Carbopol 5984.