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International Journal of Polymer Science
Volume 2017, Article ID 3728485, 10 pages
https://doi.org/10.1155/2017/3728485
Research Article

Bioactive 3D-Shaped Wound Dressings Synthesized from Bacterial Cellulose: Effect on Cell Adhesion of Polyvinyl Alcohol Integrated In Situ

1Facultad de Ingeniería Química, Universidad Pontificia Bolivariana, Circular 1, No. 70-01, Medellín, Colombia
2School of Health Sciences, Universidad de Antioquia, Calle 51D 62-29, Medellín, Colombia
3Facultad de Ingeniería Agroindustrial, Universidad Pontificia Bolivariana, Circular 1, No. 70-01, Medellín, Colombia
4Biobased Colloids and Materials Group (BiCMat), Department of Forest Product Technology, Aalto University, School of Chemical Technology, Espoo, Finland
5Facultad de Medicina, Universidad Pontificia Bolivariana, Calle 78B No. 72A-109, Medellín, Colombia
6Facultad de Ingeniería Textil, Universidad Pontificia Bolivariana, Circular 1, No. 70-01, Medellín, Colombia

Correspondence should be addressed to Cristina Castro; oc.ude.bpu@ortsac.anitsirc

Received 5 March 2017; Accepted 1 August 2017; Published 18 September 2017

Academic Editor: Miriam H. Rafailovich

Copyright © 2017 Marlon Osorio et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We investigated wound dressing composites comprising fibrils of bacterial cellulose (BC) grown by fermentation in the presence of polyvinyl alcohol (PVA) followed by physical crosslinking. The reference biointerface, neat BC, favoured adhesion of fibroblasts owing to size exclusion effects. Furthermore, it resisted migration across the biomaterial. Such effects were minimized in the case of PVA/BC membranes. Therefore, the latter are suggested in cases where cell adhesion is to be avoided, for instance, in the design of interactive wound dressings with facile exudate control. The bioactivity and other properties of the membranes were related to their morphology and structure and considered those of collagen fibres. Bioactive materials were produced by simple 3D templating of BC during growth and proposed for burn and skin ulcer treatment.