Thermal Synthesis of Polypeptides from N-Butyloxycarbonyl Oligopeptides Containing Aspartyl Residue at C-Terminus

Table 1

Weight decrease in the heating reaction of substrate peptides.

Substrate	Temperature/°C	Reaction time/h	Weight/mg		Weight decrease
			Initial	Later	mg	%
Boc-Gly-L-Asp (5a)	110	24	145	88	57	39
	120	24	145	89	56	39
	130	1	145	92	53	37
	130	2	143	86	57	40
	130	4	146	86	60	41
	130	8	146	83	63	43
	130	16	148	84	64	43
	130	24	145	84	61	42
	150	2	146	81	65	45
	170	2	147	80	67	46
Boc-L-Ala-L-Asp (5b)	120	1	161	120	41	25
	120	2	151	117	34	23
	120	4	162	121	41	25
	130	1	146	92	54	37
	130	2	174	100	74	43
	130	4	179	99	80	45
Boc-L-Val-L-Asp (5c)	110	1	164	160	4	2
	110	2	160	132	28	18
	110	4	163	126	37	23
	120	1	161	134	27	17
	120	2	186	160	26	14
	120	4	169	115	54	32
	130	1	170	141	29	17
	130	2	165	116	49	30
	130	4	166	109	57	34
Boc-Gly-Gly-L-Asp (5d)	120	1	113	107	6	5
	120	2	107	99	8	7
	120	4	110	74	36	33
	130	1	109	80	29	27
	130	2	104	69	35	34
	130	4	104	71	33	32