Research Article
Enhancing Antidepressant Effect of Poloxamer/Chitosan Thermosensitive Gel Containing Curcumin-Cyclodextrin Inclusion Complex
Table 2
Effect of thermoreversible gel on reserpine-induced ptosis, akinesia, and hypothermia.
| Treatment | Dose (mg/kg) | Ptosis mean score | Akinesia (mice number) | Rectal temperature (°C) |
| Control | - | 0 | 0 | 37.3 ± 0.54 | Reserpine | 2.0 | 2.00 ± 0.67 | 9 | 34.75 ± 0.78 | Fluoxetine hydrochloride | 15 | 1.10 ± 0.32 | 7 | 35.91 ± 0.53 | Curcumin | 15 | 1.82 ± 0.97 | 8 | 35.11 ± 0.98 | Thermoreversible gel | 0.18 | 1.20 ± 0.63 | 8 | 35.69 ± 1.02 | 0.36 | 1.10 ± 0.74 | 7 | 36.25 ± 1.09 | 0.72 | 1.00 ± 0.47 | 6 | 36.7 ± 0.82 |
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compared with control group; , compared with reserpine. |