Comparison of Rheological, Drug Release, and Mucoadhesive Characteristics upon Storage between Hydrogels with Unmodified or Beta-Glycerophosphate-Crosslinked Chitosan

Table 1

Composition of hydrogels with unmodified CS (F1, F2) or bGP-crosslinked CS (F3, F4).

Ingredient (g)	Category	Hydrogel with
		Unmodified CS		bGP-modified CS
		F1	F2	F3	F4
CS	Gelling agent	3.0	4.0	3.0	4.0
bGP 45% ()	Ion crosslinker	—	—	4.2	5.6
Clotrimazole	API	2.0	2.0	2.0	2.0
Glycerolum	Humectant	5.0	5.0	5.0	5.0
Cremophor EL	Solubilizer	6.0	6.0	6.0	6.0
D-Glucono-1,5-lactone and sodium benzoate	Preservative	1.0	1.0	1.0	1.0
Acetic acid	Vehicle	Up to 100.0	Up to 100.0	Up to 100.0	Up to 100.0