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International Journal of Polymer Science
Volume 2018, Article ID 3970142, 7 pages
Research Article

Synthesis, Characterization, and Anti-Phytopathogen Evaluation of 6-Oxychitosan Derivatives Containing N-Quaternized Moieties in Its Backbone

Kun Gao,1,2,3,4 Yukun Qin,1,2,3 Song Liu,1,2,3 Ronge Xing,1,2,3 Huahua Yu,1,2,3 Xiaolin Chen,1,2,3 Kecheng Li,1,2,3 and Pengcheng Li1,2,3

1Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, No. 7 Nanhai Road, Qingdao 266071, China
2Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, No. 1 Wenhai Road, Qingdao 266237, China
3Center for Ocean Mega-Science, Chinese Academy of Sciences, Qingdao 266071, China
4University of Chinese Academy of Sciences, Beijing 100049, China

Correspondence should be addressed to Yukun Qin; and Pengcheng Li;

Received 12 April 2018; Accepted 20 June 2018; Published 1 August 2018

Academic Editor: Miriam H. Rafailovich

Copyright © 2018 Kun Gao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The structure modification of chitosan has great application potential. 6-Oxychitosan was prepared by specially oxidizing the C6-OH of chitosan, then 6-oxychitosan was reacted with three kinds of aldehydes to prepare N-quaternized 6-oxychitosan derivatives in this paper. The derivatives were characterized by FT-IR, NMR, and elemental analysis. The antimicrobial activity of these derivatives was tested against two common plant-threatening fungi and three plant disease bacteria. The results showed that N-quaternized 6-oxychitosan derivatives had good water-solubility and excellent antimicrobial activity. Moreover, derivative 3 which connected 8-hydroxyquinolines had the highest antimicrobial activity than the other derivatives. The inhibitory indices of derivative 3 against V. albo-atrum and P. hibernalis are 89.1% and 72.8% at 0.4 mg/ml. The MICs of 3 against X. oryzae, P. syringae, and E. rhapontici were 625, 625, and 156 mg/l, respectively. All the results indicate that derivative 3 has the potential of becoming an alternative to harmful agricultural chemicals.