Review Article
Analytical Methods to Characterize and Purify Polymeric Nanoparticles
Table 1
Analytical chromatographic techniques.
| Technique | Characteristics that analyses | Advantages | Disadvantages | References |
| Gel permeation chromatography (GPC) | Molecular weight | Rapid and simple | Interaction sample with column filling | Williams [10] | High resolution | Neverova and Van Eyk [8] | Cho et al. [1] |
| High-performance liquid chromatography (HPLC) | Quantification of actives | High resolution | Interaction sample with column filling | Neverova and Van Eyk [8] | Purification | Rapid and easy performance | Sapsford et al. [9] | Low cost/sample | Small sample volumes |
| Size exclusion chromatography (SEC) | Molecular weight | High resolution | Interaction sample with column filling | Kostanski et al. [25] | Rapid and simple | Need of a labelling tag | Sapsford et al. [9] | Rebolj et al. [26] |
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