Analytical Methods to Characterize and Purify Polymeric Nanoparticles

Table 1

Analytical chromatographic techniques.

Technique	Characteristics that analyses	Advantages	Disadvantages	References
Gel permeation chromatography (GPC)	Molecular weight	Rapid and simple	Interaction sample with column filling	Williams [10]
		High resolution		Neverova and Van Eyk [8]
				Cho et al. [1]
High-performance liquid chromatography (HPLC)	Quantification of actives	High resolution	Interaction sample with column filling	Neverova and Van Eyk [8]
	Purification	Rapid and easy performance		Sapsford et al. [9]
		Low cost/sample
		Small sample volumes
Size exclusion chromatography (SEC)	Molecular weight	High resolution	Interaction sample with column filling	Kostanski et al. [25]
		Rapid and simple	Need of a labelling tag	Sapsford et al. [9]
				Rebolj et al. [26]