Study on the Role of the Inclusion Complexes with 2-Hydroxypropyl-β-cyclodextrin for Oral Administration of Amiodarone

Table 10

Pharmacokinetic parameters of pure AMD suspension and F and Fc0 formulations in Wistar rats following single-dose oral administration (, ).

Pharmacokinetic parameter	Pure AMD suspension	Formulation F	Formulation Fc
(ng/mL)
(h)
(ng/mLh)
(ng/mLh)
(h^-1)
(h)
(%)		111.4^a	501.9^a; 450.1^b

: peak plasma concentration; : time to reach peak plasma concentration; : area under curve from 0 h to last determined experimental data; : area under the plasma concentration time curve from time zero to infinity; : elimination rate constant; : elimination half-life; : systemic relative bioavailability. ^aWith reference to pure AMD suspension; ^bwith reference to formulation F1. vs. AMD.