Study on the Role of the Inclusion Complexes with 2-Hydroxypropyl-β-cyclodextrin for Oral Administration of Amiodarone
Table 9
,, and of pure AMD suspension and F10 and F1 formulations in Wistar rats following single oral administration (,).
Group
(ng/mL)
(h)
(mg/mLh)
Pure AMD suspension
Formulation F
Formulation Fc
Pure AMD suspension
Formulation F
Formulation Fc
Pure AMD suspension
Formulation F
Formulation Fc
1
130
216
860
5
5
8
1373.38
4925.13
21905.88
2
145
229
501
8
8
8
3954.50
3472.88
14752.50
3
78
374
515
8
3
8
2072.63
2548.25
11236.25
4
241
319
769
4
2
4
3119.00
2322.25
15540.75
5
187
261
719
4
6
6
2829.50
4197.50
16160.00
6
266
99
418
4
6
4
4440.00
2678.25
8889.00
Average
174.50
249.67
630.33
5.50
5.00
6.33
2964.83
3357.38
14747.40
SD
70.87
94.50
151.37
1.97
2.19
2.00
1142.49
1035.80
3123.50
CV (%)
40.61
37.85
24,01
35.91
43.82
31.58
38.53
30.85
21.18
Cmax: peak plasma concentration; : time to reach peak plasma concentration; : area under the curve from 0 h to last determined experimental data; SD: standard deviation; CV: coefficient of variation.
