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International Journal of Polymer Science
Volume 2019, Article ID 6062381, 7 pages
https://doi.org/10.1155/2019/6062381
Research Article

Piroxicam-Collagen-Based Sponges for Medical Applications

1University Politehnica of Bucharest, Faculty of Applied Chemistry and Materials Science, General Chemistry Department, 1-7 Gh. Polizu Str., 011061 Bucharest, Romania
2“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Physical and Colloidal Chemistry Department, 6 Traian Vuia Str., 020956 Bucharest, Romania
3INCDTP-Division Leather and Footwear Research Institute, Collagen Department, 93 Ion Minulescu Str., 031215 Bucharest, Romania

Correspondence should be addressed to Ileana Rău; moc.oohay@asudnarb_anaeli and Roxana Gabriela Zgârian; moc.oohay@anaxornairigz

Received 19 September 2018; Revised 20 January 2019; Accepted 4 March 2019; Published 29 May 2019

Guest Editor: Patrizia Paolicelli

Copyright © 2019 Daniel-Cristian Ioan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Depending on the concentration of the drug and/or the method of administration, drugs could be used in various ways. To take full advantage of the drug beneficial properties in oral medical interventions but also in other types of surgery, like plastic surgery, general surgery, or gynecological surgery, the drug concentration as well as the administration method itself will depend on the wound, type of surgery, and severity of the postoperative pain which can be very different. Generally, the local administration methods are recommended. Piroxicam, a nonsteroidal anti-inflammatory drug (NSAID) of the oxicam class, is generally used to relieve the symptoms of pain and inflammation. Starting from the idea of the special benefit of the interference between collagen-based materials and drug beneficial properties, our work was focused on the synthesis and characterization of new collagen-piroxicam materials. These new collagen-based materials present a good water absorption, and the piroxicam release suggests a biphasic drug release profile whereas the obtained values for the release exponent revealed a complex release mechanism including swelling, diffusion, and erosion.