Highly Porous pH-Responsive Carboxymethyl Chitosan-Grafted-Poly (Acrylic Acid) Based Smart Hydrogels for 5-Fluorouracil Controlled Delivery and Colon Targeting

Figure 5

Release of 5-FU from Poly (CMCS-g-AA) hydrogels using different contents of EGDMA as crosslinking agent (0.25%, 0.50%, and 1% of AA) at various pH values and 37°C in 0.05 M USP phosphate buffer solution.