Evaluation of 4-tert-Butyl-Benzhydrylamine Resin (BUBHAR) as an Alternative Solid Support for Peptide Synthesis

Table 1

Bead swelling^a values of methylbenzhydrylamine resin (MBHAR) and 4-tert-butyl-benzhydrylamine resin (BUBHAR) batches in different solvent systems.

Solvent	(AN+DN)^b	Swelling values of resins (%)
		Batches of MBHAR (mmol/g)				Batches of BUBHAR (mmol/g)
		0.49	0.70	1.20	Average values	0.35	0.75	1.10	Average values
DCM	21.4	70	54	64	63	68	72	81	74
DMF	42.6	46	48	46	47	76	75	72	74
50% DCM/DMF	32.0	62	51	51	55	72	71	82	75
20% DMSO/NMP	42.3	62	58	63	61	58	70	82	70
MeOH	71.3	29	29	24	27	41	56	31	43
		Average values			51	Average values			67

^ab; polarity values of solvent according to ref. [17].