Progress on Preparation of pH/Temperature-Sensitive Intelligent Hydrogels and Applications in Target Transport and Controlled Release of Drugs

Table 2

Applications of different hydrogels in controlled drug releasing.

Type of response	Hydrogel polymers	Drugs	Duration	References
pH-sensitive	Hemicellulose grafted polyacrylic acid	Aspirin	12 h	[73]
	Chitosan (CS)-polyvinyl alcohol (PVA)	Dexamethasone/aspirin	7 h	[74]
	Polyacrylic acid	Prednisolone	5 h	[75]
	Chitosan (CS)-polyvinyl pyrrolidone (PVP)	Oral antibiotic	in 3 h ()	[76]
Temperature-sensitive	Polypropyl caprolactone glutamic acid	TAX	21d	[77]
	Chitosan/sodium glycerophosphate	PYM	18d	[78]
	Polyglycolic acid and polylactic acid	Cytarabine	10d	[79]
	Poly (N-PNIPAM)-carboxymethyl chitosan	cis-Platinum	16d	[80]
pH temperature-sensitve	Four-arm polyethylene glycol-polyurethane	Chlorambucil	14d	[62]
	Pluronic-polyacrylic acid	Pharmorubicin	12 h	[64]
	Poly β-carbamic acid ester/polyethylene glycol	Adriamycin amycin	35 d	[63]
	(N-PNIPAM-cocrylic acid)	Riboflavin (vitamin B2)	in 7 h (, ). in 3.5 h (, )	[81]