Antiskin Cancer and Antioxidant Activities of Formulated Agar from Brown Seaweed Laminaria digitata (Hudson) in Dimethyl Benzanthracene-Induced Swiss Albino Mice
Table 1
Experimental design.
Group 1
Normal control mice (normal diet and water)
Group 2
Cancer-induced mice (100 nM DMBA dissolved in 200 μl acetone was applied topically weekly twice for four weeks)
Group 3
FA (low dose)—60 mg/ml in 200 μl acetone was applied topically weekly twice for four weeks, 30 min before DMBA exposure (100 nM DMBA dissolved in 200 μl acetone was applied topically weekly twice)
Group 4
FA (high dose)—120 mg/ml in 200 μl acetone was applied topically weekly twice for four weeks, 30 min before DMBA exposure (100 nM DMBA dissolved in 200 μl acetone was applied topically weekly twice)
Group 5
Positive control: 5-FU-100 mg/ml in 100 ml acetone was applied topically weekly twice for four weeks, 30 min before DMBA exposure (100 nM DMBA dissolved in 200 μl acetone was applied topically weekly twice)