Recent Advances on Bacterial Cellulose-Based Wound Management: Promises and Challenges

Table 4

A summary of BC-based wound dressing with antibacterial and anti-inflammatory properties.

Incorporated agent	Therapeutic purpose	Wound model	Animal model	Dressing type	Major findings	Reference
Amoxicillin	Antibacterial properties	Skin	Mice	Sponge	Excellent wound healing	[169]
Polihexamide/PEG	Antibacterial properties	Skin	Mice	Membrane	Accelerated in vivo wound healing	[100]
ε-Polylysine	Antibacterial properties	Infected	Sprague–Dawley rats	Membrane	Greater newborn skin thickness	[171]
Glybenclamide	Antibacterial properties	Diabetic	Sprague–Dawley rats	Nanofiber	Fewer systemic side effects and better wound recovery	[172]
Metformin	Antibacterial properties	Diabetic	Sprague–Dawley rats	Nanofiber	Fewer systemic side effects and better wound recovery	[172]
Fluconazole	Antibacterial and antifungal properties	Second-degree	Wistar rat	Membrane	Higher healing rate	[138]
Thymol	Antibacterial properties	Third-degree	Wistar rat	Hydrogel	Promoted wound closure	[111]
Chitosan	Antibacterial properties	Panniculus carnosus	Dawley rats	Membrane	Faster epithelization and regeneration	[110]
Acrylic acid	Antibacterial properties	Partial-thickness Burn	Sprague–Dawley rats	Hydrogel	Faster wound-healing, enhanced epithelialization, and accelerated fibroblast proliferation	[128]
Lidocaine	Anti-inflammatory properties	Skin	Wistar rat	Membrane	Mild inflammatory infiltrate, better collagen fiber organization	[175]
Betulin diphosphate	Anti-inflammatory properties	Skin	Wistar rat	Membrane	Effective wound healing	[176]
Sericin and polyhexamethylene biguanide	Anti-inflammatory properties	Skin	Wistar rat	Hydrogel	Reduced pain and lowered the chronic inflammation	[177]
Sericin and polyhexamethylene biguanide	Anti-inflammatory properties	Skin	Wistar rat	Hydrogel	Significant wound repair and lower inflammatory reaction	[178]
Hydroxypropyltrimethyl ammonium chloride chitosan	Anti-inflammatory properties	Full-thickness burn	Kunming mice	Membrane	Shortened healing time	[112]
Montmorillonite	Anti-inflammatory properties	Partial-thickness burn	Balb mice	Hydrogel	Enhanced wound healing and tissue regeneration	[179]