Development and Evaluation of Amlodipine-Polymer Nanocomposites Using Response Surface Methodology

Table 2

ANOVA table for % LE, particle size, and zeta potential.

LE model	DF	Adj SS	Adj MS	F-value	T-value	P-value	VIF
Model	11	3593.37	326.67	75.51		0.000
Linear	4	3227.12	806.78	186.48		0.000
Al	1	812.55	812.55	187.81	13.70	0.000	1.21
Fe	1	2634.97	2634.97	609.05	24.68	0.000	1.13
Polymer	1	32.09	32.09	7.42	2.72	0.011	1.15
pH	1	128.96	128.96	29.81	–5.46	0.000	1.18
Square	1	63.09	63.09	14.58		0.001
Al*Al	1	63.09	63.09	14.58	3.82	0.001	1.01
2-way interaction	6	370.27	61.71	14.26		0.000
Al*Fe	1	249.01	249.01	57.56	7.59	0.000	1.21
Al*polymer	1	0.80	0.80	0.18	–0.43	0.671	1.12
Al*pH	1	41.99	41.99	9.70	–3.12	0.004	1.11
Fe*polymer	1	21.92	21.92	5.07	2.25	0.032	1.15
Fe*pH	1	0.45	0.45	0.10	–0.32	0.748	1.18
Polymer*pH	1	8.68	8.68	2.01	–1.42	0.167	1.07
Error	31	134.12	4.33
Lack-of-fit	4	20.16	5.04	1.19		0.336
Pure error	27	113.96	4.22
Total	42	3727.49
Size model
Model	11	268,342	24,395	60.00	15.30	0.000
Linear	4	74,622	18,655	45.88		0.000
Al	1	17,902	17,902	44.03	6.64	0.000	1.08
Fe	1	2033	2033	5.00	–2.24	0.033	1.12
Polymer	1	39,970	39,970	98.30	–9.91	0.000	1.13
pH	1	23,219	23,219	57.11	7.56	0.000	1.13
Square	1	10,611	10,611	26.10		0.000
Al*Al	1	10,611	10,611	26.10	5.11	0.000	1.06
2-way interaction	6	159,695	26,616	65.46		0.000
Al*Fe	1	105,767	105,767	260.13	–16.13	0.000	1.63
Al*polymer	1	59,821	59,821	147.13	12.13	0.000	1.83
Al*pH	1	9202	9202	22.63	–4.76	0.000	1.93
Fe*polymer	1	7306	7306	17.97	4.24	0.000	1.97
Fe*pH	1	13,036	13,036	32.06	–5.66	0.000	1.87
Polymer*pH	1	3396	3396	8.35	2.89	0.007	1.68
Error	30	12,198	407
Lack-of-fit	3	2351	784	2.15		0.117
Pure error	27	9847	365
Total	41	280,540
Potential model
Model	11	22725.5	2066.0	492.87	–5.05	0.000
Linear	4	19117.2	4779.3	1140.19		0.000
Al	1	65.6	65.6	15.65	3.96	0.000	2.12
Fe	1	57.4	57.4	13.71	–3.70	0.001	1.81
Polymer	1	170.5	170.5	40.67	–6.38	0.000	1.20
pH	1	12388.1	12388.1	2955.42	–54.36	0.000	1.75
Square	1	283.5	283.5	67.63		0.000
Al*Al	1	283.5	283.5	67.63	8.22	0.000	1.07
2-way interaction	6	62.1	10.4	2.47		0.049
Al*Fe	1	7.5	7.5	1.79	1.34	0.192	1.92
Al*polymer	1	0.5	0.5	0.11	–0.34	0.738	1.20
Al*pH	1	8.8	8.8	2.10	1.45	0.159	1.62
Fe*polymer	1	31.0	31.0	7.41	–2.72	0.011	1.19
Fe*pH	1	2.2	2.2	0.51	–0.72	0.480	1.77
Polymer*pH	1	0.2	0.2	0.05	–0.23	0.818	1.08
Error	27	113.2	4.2
Lack-of-fit	3	15.4	5.1	1.26		0.310
Pure error	24	97.8	4.1
Total	38	22838.6