Development and Evaluation of Amlodipine-Polymer Nanocomposites Using Response Surface Methodology

Table 3

Comparative results between observed and predicted response values of variables of optimized formulation.

Concentrations	Experimental response	Predicted values	Observed values	Bias (%)
Al (2.4 g); Fe (2.4 g); Polymer (0.05 g)	LE (%)	40.5%	35.1%	–; 13.33%
	Particle size (nm)	151 nm	170 nm	12.58%
	Zeta potential (mV)	33.92 mV	35.1 mV	3.47%
Al (1.58 g); Fe (1.60 g); Polymer (0.12 g)	LE (%)	19.7%	22.1%	12.18%
	Particle size (nm)	156 nm	168 nm	7.69%
	Zeta potential (mV)	3.33 mV	3.29 mV	–1.20%
Al (2.02 g); Fe (0.99 g); Polymer (0.08 g)	LE (%)	15.8%	20.2%	27.84%
	Particle size (nm)	229 nm	238 nm	3.93%
	Zeta potential (mV)	6.26 mV	5. 97 mV	–4.63%

%Bias was calculated as ((observed value – predicted value)/predicted value) × 100.