Silymarin and Vanillic Acid Silver Nanoparticles Alleviate the Carbon Tetrachloride-Induced Nephrotoxicity in Male Rats
Table 2
Effect of treating CCl4-induced nephrotoxicity in male rats with vanillic acid, vanillic acid AgNPs, and silymarin on antioxidant enzymes (GST, GSH, SOD, and CAT) and TAC.
Antioxidant kidney tissue (U/g)
Statistics
G1 (negative control)
G2 (positive control)
G3 (treated with vanillic)
G4 (treated with vanillic acid AgNPs)
G5 (treated with silymarin)
GST (U/g)
Mean ± SE
a
e
d
c
b
LSD 0.05 = 8.808
T-test
—
39.89***
−07.37***
−42.95***
−41.67***
GSH (mmol/g)
Mean ± SE
a
e
b
c
b
LSD 0.05 = 7.407
T-test
—
051.25***
−024.79***
−286.18***
−005.76***
TAC (IU/g)
Mean ± SE
a
e
d
c
b
LSD 0.05 = 0.329
T-test
—
20.41***
−41.92***
−15.25***
−23.19***
SOD (IU/g)
Mean ± SE
a
d
c
c
0b
LSD 0.05 = 12.552
T-test
—
13.95***
−08.31***
−14.04***
−11.95***
CAT (mmol/g)
Mean ± SE
a
e
d
c
b
LSD 0.05 = 0.210
T-test
—
23.87***
−13.86***
−45.02***
−28.41***
T-test values ***: significant at . ANOVA analysis: means with different superscripts (a, b, c, d, or e) are significantly different at . LSD: least significant difference.
