Microscopic Polyangiitis in Systemic Sclerosis

Table 3

Differences in vascular clinical findings between SSc and MPA.

	SSc	MPA
Raynaud’s phenomenon	+	−
digital ischemia	+	−
skin ulcers	+	+
skin nodules	−	+
Purpura	−	+
nail bed change/telangiectasia	+	−
Myositis	+	+
interstitial pneumonia	+	+
honeycomb lung	+	−
alveolar hemorrhage	−	+
pulmonary hypertension	+	−
RPGN	−	+
scleroderma renal crisis	+	−
mononeuritis multiplex	−	+
CNS vasculitis	−	+
Histological findings;
fibrinoid necrosis	arteries, arterioles	capillaries, arterioles
intimal hyperplasia	+	−
capillaritis	−	+
pFNCGN	−	+

SSc: scleroderma
MPA: microscopic polyangiitis
RPGN: rapidly progressive glomerulonephritis
CNS: central nervous system
pFNCGN: pauci-immune focal necrotizing crescentic glomerulonephritis.