Risk Factors for Radiographic Tibiofemoral Knee Osteoarthritis: The Wuchuan Osteoarthritis Study
Table 3
Risk factors for the radiographic tibiofemoral, lateral compartment, and medial compartment knee OA.
Group
rTFKOA1
LCKOA2
MCKOA3
No. (%) of subjects
ORs* (95% CI)
P for trend
No. (%) of subjects
ORs (95% CI)
P for trend
No. (%) of subjects
ORs (95% CI)
P for trend
Age
1 (youngest)
24 (6.9)
0.065 (0.034–0.123)
<.001
11 (3.2)
0.28 (0.11–0.69)
.006
11 (3.2)
0.037 (0.017–0.082)
<.001
2
37 (10.4)
0.12 (0.064–0.21)
<.001
12 (3.4)
0.32 (0.13–0.77)
.012
24 (6.7)
0.089 (0.047–0.17)
<.001
3
53 (26.0)
0.50 (0.29–0.85)
.010
20 (9.8)
1.1 (0.49–2.5)
.818
38 (18.6)
0.39 (0.22–0.70)
.001
4 (oldest)
41 (35.0)
1.0
10 (8.5)
1.0
35 (29.9)
1.0
Sex
1 (male)
53 (10.5)
0.45 (0.30–0.67)
<.001
18 (3.6)
0.48 (0.26–0.88)
.017
37 (7.3)
0.40 (0.25–0.64)
<.001
2 (female)
102 (19.6)
1.0
35 (6.7)
1.0
71 (13.7)
1.0
BMI
1 (thinnest)
11 (14.5)
0.15 (0.06–0.38)
<.001
6 (7.9)
1.69 (0.37–7.59)
.497
8 (10.5)
0.13 (0.043–0.36)
<.001
2
91 (12.2)
0.21 (0.11–0.40)
<.001
32 (4.3)
1.09 (0.31–3.81)
.894
66 (8.9)
0.20 (0.095–0.42)
<.001
3
32 (23.2)
0.60 (0.29–1.21)
.153
12 (8.7)
2.36 (0.62–8.95)
.208
19 (13.8)
44 (0.19–1.00)
.051
4 (fattest)
21 (31.8)
1.0
3 (4.5)
1.0
15 (22.7)
1.0
Injury
0 (no)
137 (14.4)
0.43 (0.23–0.81)
.009
45 (4.7)
0.31 (0.13–0.71)
.006
97 (10.2)
0.52 (0.24–1.10)
.085
1 (yes)
17 (23.6)
1.0
8 (11.1)
1.0
11 (15.3)
1.0
Workload4
3 (moderate)
20 (23.8)
0.81 (0.44–1.48)
.487
9 (10.7)
1.30 (0.57–2.99)
.536
14 (16.7)
0.66 (0.33–1.32)
.240
4 (heavy)
134 (14.3)
1.0
43 (4.6)
1.0
93 (10.0)
1.0
Driving
<2 h/d
149 (16.3)
1.12 (0.44–2.83)
.809
50 (5.5)
0.89 (0.24–3.25)
.861
104 (11.4)
0.94 (0.31–2.87)
.912
≥2 h/d
6 (5.3)
1.0
3 (2.7)
1.0
4 (3.5)
1.0
Cycling
<2 h/d
127 (15.6)
0.71 (0.44–1.16)
.175
44 (5.4)
0.93 (0.43–2.01)
.844
90 (11.0)
0.75 (0.42–1.34)
.33
≥2 h/d
28 (13.4)
1.0
9 (4.3)
1.0
18 (8.6)
1.0
Digging
<2 h/d
102 (14.3)
0.72 (0.48–1.08)
.109
35 (4.9)
0.65 (0.35–1.21)
.178
74 (10.3)
0.86 (0.54–1.38)
.532
≥2 h/d
53 (17.1)
1.0
18 (5.8)
1.0
34 (11.0)
1.0
Kneeling
<0.5 h/d
78 (14.3)
0.93 (0.64–1.35)
.690
24 (4.4)
0.83 (0.47–1.47)
.529
56 (10.3)
0.99 (0.64–1.53)
.962
≥0.5 h/d
77 (16.0)
1.0
29 (6.0)
1.0
52 (10.8)
1.0
Squatting
<0.5 h/d
58 (17.4)
1.25 (0.85–1.84)
.267
28 (8.4)
2.67 (1.50–4.76)
.001
40 (12.0)
1.15 (0.73–1.80)
.545
≥0.5 h/d
97 (14.0)
1.0
25 (3.6)
1.0
68 (9.8)
1.0
Lifting5
0 (no)
20 (23.0)
0.99 (0.55–1.80)
.976
8 (9.2)
0.76 (0.31–1.86)
.549
15 (17.2)
0.94 (0.49–1.81)
.849
1 (yes)
135 (14.4)
1.0
45 (4.8)
1.0
93 (9.9)
1.0
Oddsratios (ORs) were adjusted for age, sex, BMI, and knee injury. Radiographic tibiofemoral, lateral compartment, and medial compartment knee OA. Lateral compartment knee OA. Medial compartment knee OA. The subgroup “2” representing light physical activity was not included in analysis for its number of subjects was too small (only 8). Lift or move objects weighing 10 kilograms or more almost everyday.
