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International Journal of Rheumatology
Volume 2010 (2010), Article ID 969383, 6 pages
http://dx.doi.org/10.1155/2010/969383
Clinical Study

Serum Endoglin Levels in Patients Suffering from Systemic Sclerosis and Elevated Systolic Pulmonary Arterial Pressure

1Rheumatology Section, Fundación Santa Fe de Bogotá, School Medicine Universidad de los Andes, Bogotá, Colombia
2Rheumatology Unit, Universidad Nacional de Colombia, Bogotá, Colombia
3Biochemistry Unit, Universidad Nacional de Colombia, Bogotá, Colombia

Received 16 April 2010; Revised 11 June 2010; Accepted 20 July 2010

Academic Editor: Lorinda Chung

Copyright © 2010 Paola Ximena Coral-Alvarado et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Pulmonary arterial hypertension (PAH) is the main cause of morbimortality in systemic sclerosis (SSc). Increased Eng expression has been demonstrated in SSc patients. Objective. Ascertaining serum levels of Eng in SSc patients with and without elevated systolic pulmonary arterial pressure (sPAP) and comparing them with that of healthy volunteers. Methods. A cross-sectional study was carried out. A commercial ELISA kit was used for measuring serum concentrations of Eng in 60 subjects: 40 patients with SSc with and without elevated sPAP, compared to 20 healthy control subjects. Elevated sPAP was detected by echocardiogram. Results. No association between positive Eng and elevated sPAP was found when compared to the SSc without elevated sPAP group ( ; 0.65–12.88 95% CI; ); however, an association was found between positive Eng and elevated sPAP compared to healthy controls ( ; 2.46–1050.33 95% CI; ), and weak association was found between the positive Eng with SSc without elevated sPAP group compared to healthy controls ( , 0.8–393.74 95% CI; ). Conclusion. Raised serum levels of Eng in SSc patients compared to healthy controls were found, suggesting a role for Eng in SSc vasculopathy and not just in elevated sPAP. However, prospective studies are needed to verify such observations.