Cost-Effectiveness Evaluation of Etoricoxib versus Celecoxib and Nonselective NSAIDs in the Treatment of Ankylosing Spondylitis in Norway
Table 4
Estimated effects and costs by treatment (base-case scenario).
Etoricoxib (90 mg)
Celecoxib (200 & 400 mg)
Diclofenac (150 mg)
Naproxen (1000 mg)
Estimate
95% CrI
Estimate
95% CrI
Estimate
95% CrI
Estimate
95% CrI
Life years
1 yrs
1
1
1
1
1
1
1
1
1
1
1
1
5 yrs
4.59
4.59
4.60
4.59
4.59
4.60
4.59
4.59
4.59
4.59
4.59
4.60
30 yrs
16.72
16.69
16.76
16.76
16.73
16.79
16.73
16.69
16.76
16.76
16.71
16.80
QALYs
1 yrs
0.74
0.66
0.80
0.67
0.59
0.75
0.69
0.61
0.76
0.70
0.62
0.77
5 yrs
3.34
3.02
3.64
3.14
2.78
3.48
3.17
2.82
3.50
3.22
2.88
3.54
30 yrs
11.16
9.85
12.42
10.66
9.24
12.04
10.71
9.30
12.08
10.80
9.41
12.15
(best)2
98.90%
at 1 year
0.00%
at 1 year
0.13%
at 1 year
0.98%
at 1 year
98.94%
at 5 years
0.00%
at 5 years
0.11%
at 5 years
0.95%
at 5 years
99.96%
at 30 years
0.00%
at 30 years
0.00%
at 30 years
0.04%
at 30 years
Treatment cost (NOK)
1 yrs
4,654
4,654
4,654
4,977
4,977
4,977
1,588
1,588
1,588
1,380
1,380
1,380
5 yrs
50,020
41,400
62,060
74,940
62,790
89,160
60,250
44,380
80,180
59,030
43,100
79,000
30 yrs
628,200
463,300
823,600
740,500
544,400
971,100
710,400
517,500
937,800
708,900
516,200
936,000
GI event costs (NOK)
1 yrs
109
69
158
124
65
214
236
144
341
236
144
341
5 yrs
554
360
784
648
391
977
939
576
1,356
943
579
1,361
30 yrs
1,159
743
1,644
1,069
654
1,579
1,453
873
2,148
1,469
881
2,173
Thrombotic CV event costs (NOK)
1 yrs
1,148
1,027
1,278
1,148
1,027
1,278
1,208
1,082
1,345
714
360
1,271
5 yrs
5,065
4,617
5,542
4,871
4,476
5,289
5,081
4,535
5,672
3,654
2,590
5,309
30 yrs
10,060
8,452
11,650
7,696
6,712
8,756
8,293
6,852
9,920
6,541
4,888
8,833
Other AE costs (NOK)
1 yrs
202
146
268
202
146
268
120
77
171
120
77
171
5 yrs
814
612
1,048
723
555
918
502
323
718
504
324
720
30 yrs
1,507
1,098
1,991
1,048
795
1,342
820
513
1,201
828
517
1,214
Total costs (NOK)
1 yrs
6,115
5,974
6,267
6,452
6,300
6,618
3,152
2,981
3,332
2,449
2,073
3,015
5 yrs
56,450
47,920
68,450
81,190
69,120
95,230
66,780
51,010
86,440
64,130
48,120
84,220
30 yrs
640,900
476,900
835,600
750,300
554,500
980,800
721,000
528,800
947,700
717,800
526,000
944,700
(best)2
0.00%
at 1 year
0.00%
at 1 year
1.15%
at 1 year
98.85%
at 1 year
85.26%
at 5 years
0.00%
at 5 years
0.18%
at 5 years
14.57%
at 5 years
98.92%
at 30 years
0.01%
at 30 years
0.03%
at 30 years
1.04%
at 30 years
1All results are discounted, 4.0% for effects and costs. 2Probability that a certain intervention provides best outcomes (i.e., greatest QALYs, lowest costs).
