Review Article
B-Cell Depletion Therapy in Systemic Sclerosis: Experimental Rationale and Update on Clinical Evidence
Table 1
Studies assessing the efficacy of RTX in SSc.
| | | | | | | | | Outcomes | | | | | | | | | Skin | | Lung function tests | Functional status | | Study | Number of participants | Study type | Evaluation time point(months) | Number of RTX courses | | | | | | | | Clinical assessment | histologic improvement (yes/no) | Skin B-cell depletion |
| | Smith et al. | 8 | Open label, uncontrolled | 6 | 1 | Improved | Yes | In 4 patients | Stable | Stable |
| | Lafyatis et al. | 15 | Open label, uncontrolled | 6/12 | 1 | Stable | Yes | Yes | Stable | Stable |
| | Daoussis et al. | 8 | Open label, randomized controlled | 12 | 2 | Improved | Yes | Yes | Improved | Improved |
| | Boselo et al. | 9 | Open label, uncontrolled | 6–36 | 1 (3 patients receive a second cycle) | Improved | Not reported | No | Stable | Improved |
| | McGonagle et al. | 1 | Case report | — | 2 | Not reported | Not reported | — | Improved | Improved |
| | Daoussis et al. | 1 | Case report | 24 | 4 | Improved | Improved | Yes | Improved | Improved |
| | Yu | 1 | Case report | — | 1 | Not reported | Not reported | — | Improved | Improved |
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