The Many Faces of Interleukin-6: The Role of IL-6 in Inflammation, Vasculopathy, and Fibrosis in Systemic Sclerosis
Table 1
Systemic sclerosis-associated autoantibodies, potentially pathogenic antibodies which have been described in a proportion of patients with systemic sclerosis. Reviewed in [41]. ECM: extracellular matrix.
Autoantibody
In vitro activity
Antiendothelial cell
Endothelial cell apoptosis
Antifibrillin 1
Fibroblast activation, increased ECM production
Antimatrix metalloproteinase
Prevent degradation of the ECM
Anti-PDGFR
Induce collagen 1 production Convert fibroblasts to myofibroblasts