The Role of Intravenous Immunoglobulin Preparations in the Treatment of Systemic Sclerosis

Table 1

IVIG in patients with SSc.

Author/year	Number of patients	Skin lesions	Results	Remarks
Bodemer et al. 1990 [6]	1	Only in the face	Myositis improvement	SSc-dermatomyositis overlap
Levy et al. 2000 [8]	3	dcSSc	Regression of skin score, disease stabilization	No changes in PM-Scl antibodies
Levy et al. 2004 [9]	15	5 patients-lcSSc,10 patients-dcSSc	Decreased mRSS, changes in HAQ score	Very high skin score in patients with lcSSc
Nacci et al. 2007 [10]	7	5 patients-limited SSc, 2 patients diffuse SSc	Decreased VAS, IAFD, mRSS after 6-month treatment	Effects on joints and skin
Asano et al. 2005 [11]	1	Fingers, hands, forearms, upper arms, face, chest, abdomen, lower legs, dorsum of the feet	Decreased mRSS
Szekanecz et al. 2009 [12]	1	Disuse SSc, refractory to treatment	Good clinical effect	Combination of IVIG and plasmapheresis