Anti-𝜶-enolase Antibodies in Serum from Pediatric Patients Affected by Inflammatory Diseases: Diagnostic and Pathogenetic Insights

Table 3

Serum level and percentage of AAE IgA+ and AAE IgG+ in JIA stratified for clinical presentation and in HPF classified for genetic defect. Levels of anti-α-enolase IgA and IgG in patients with pauciarticular, polyarticular, or systemic juvenile idiopathic arthritis (JIA) CINCA syndrome, FMF, MKD, and TRAPS hereditary periodic fevers (HPF) were reported as mean and standard deviation (SD). Results are expressed as arbitrary units per mL (AU/mL). Patients’ AAE levels are compared by t-test (∗ = P < 0.05). Percentage of AAE IgA and IgG positivity in each disease class is also reported.

	AAE IgA (mean + SD)	AAE IgG (mean + SD)	IgA+	IgG+	IgA+ IgG+
JIA
JIA-pauci (n = 16)	30.09±28.77	39.75±13.20	7 (44%)	13 (81%)	7 (44%)
JIA-poly (n = 10)	36.98±11.62 *	49.09±14.59	8 (80%)	9 (90%)	8 (80%)
JIA-syst (n = 5)	23.26±10.0 *	38.23±5.38	1 (20%)	5 (100%)	1 (20%)
HPF
CINCA (n = 9)	29.58±16.47	55.06±12.81	6 (67%)	9 (100%)	6 (67%)
FMF (n = 5)	49.30±43.43	48.43±29.16	4 (80%)	4 (80%)	4 (80%)
MKD (n = 5)	45.33±51.28	36.52±21.99	3 (60%)	3 (60%)	2 (40%)
TRAPS (n = 1)	8.77	12.97	—	—	—