Review Article

Are Classification Criteria for IgG4-RD Now Possible? The Concept of IgG4-Related Disease and Proposal of Comprehensive Diagnostic Criteria in Japan

Table 7

Validation of a combination of CDC and organ-specific criteria for type 1 AIP.

Compared with pancreas cancer, the sensitivity of comprehensive criteria for definite/probable AIP was 0%, but 78% for possible AIP, and specificity was 100% in any groups. Although it is hard to take an enough size of specimen in diagnosis of AIP malignancy can be usually denied by EUS-FNA. Therefore, the CDC are enough for detecting possible AIP, but not for definite/probable AIP.

AIP ( )
PaCa ( )
Total ( )
JPS 2006ICDC for type 1 AIPCDC for IgG4-RD

Diagnosis of AIPDefinite AIPDefinite/probable AIPDefinite/probable AIPpossible

sensitivity70%97%0%78%
specificity100%100%100%100%
PPV100%100%0%100%
NPV49%8%100%57%
accuracy77%95%22%83

PaCa: pancreas cancer, PPV: positive predictive value, NPV: negative predictive value.