Review Article
IgG4-Related Lymphadenopathy
Table 2
Distinction between IgG4-related disease and hyper-IL-6 syndromes.
| | IgG4-related disease | Hyper-IL-6 syndromes |
| Serum immunoglobulin | IgG↑(IgG4↑), IgE↑ | IgG↑(IgG1~IgG4↑), IgA↑, IgM -/↑, IgE↑ | Serum IgG4/IgG ratio | Elevated | Normal (~sightly elevated) | Serum IL-6 | Normal (~sightly elevated) | Elevated | Serum CRP | Normal (~sightly elevated) | Elevated | Thrombocytosis | No | Yes | Anemia | No | Yes | Hypoalbuminemia | No | Yes | Hypocholesterolemia | No | Yes |
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Hyper IL-6 syndromes; multicentric Castleman’s disease, rheumatoid arthritis, and other immune-mediated conditions.
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