Review Article
IgG4-Related Lymphadenopathy
Table 2
Distinction between IgG4-related disease and hyper-IL-6 syndromes.
| | | IgG4-related disease | Hyper-IL-6 syndromes |
| | Serum immunoglobulin | IgG↑(IgG4↑), IgE↑ | IgG↑(IgG1~IgG4↑), IgA↑, IgM -/↑, IgE↑ | | Serum IgG4/IgG ratio | Elevated | Normal (~sightly elevated) | | Serum IL-6 | Normal (~sightly elevated) | Elevated | | Serum CRP | Normal (~sightly elevated) | Elevated | | Thrombocytosis | No | Yes | | Anemia | No | Yes | | Hypoalbuminemia | No | Yes | | Hypocholesterolemia | No | Yes |
|
|
Hyper IL-6 syndromes; multicentric Castleman’s disease, rheumatoid arthritis, and other immune-mediated conditions.
|
