Immunohistochemical Characteristics of IgG4-Related Tubulointerstitial Nephritis: Detailed Analysis of 20 Japanese Cases

<table>IgG4-related tubulointerstitial nephritis with IgA nephropathy. (a) Periodic acid-Schiff (PAS) staining reveals severe tubulointerstitial nephritis (PAS x100). Regional lesion distribution is evident. (b) Segmental mesangial proliferation is seen (PAS <svg height="8.5" id="M22" style="vertical-align:-0.0pt" version="1.1" viewbox="0 0 10.1 8.5" width="10.1" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,8.438)"><use xlink:href="#xD7"></use></g>
</svg>400). (c) Immunofluorescence staining for IgA reveals bright mesangial deposits (<svg height="8.5" id="M23" style="vertical-align:-0.0pt" version="1.1" viewbox="0 0 10.1 8.5" width="10.1" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,8.438)"><use xlink:href="#xD7"></use></g>
</svg>400). (d) Immunofluorescence staining for C3 reveals weak mesangial staining for C3 (<svg height="8.5" id="M24" style="vertical-align:-0.0pt" version="1.1" viewbox="0 0 10.1 8.5" width="10.1" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,8.438)"><use xlink:href="#xD7"></use></g>
</svg>400).</table>

International Journal of Rheumatology

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Figure 3

Figure 3: Immunohistochemical Characteristics of IgG4-Related Tubulointerstitial Nephritis: Detailed Analysis of 20 Japanese Cases 