Immunohistochemical Characteristics of IgG4-Related Tubulointerstitial Nephritis: Detailed Analysis of 20 Japanese Cases

Table 1

Clinical and laboratory features of IgG4-related tubulointerstitial nephritis.

Pt. no.	Age/gender	U-Prot	Cr	IgG	IgG4	IgE	CH50	C3	C4	Other organ involvement
1	76/F	—	0.59	2,990	769	267	60	110	27	Sa, Lu
2	70/M	0.26 g/day	0.90	3,496	623	NA	<12	52	2	Pa
3	59/M	—	1.10	2,319	734	542	>66.0	106	24	Sa, Pa, Pr, RP
4	63/M	0.2 g/gCr	1.20	1,756	408	513	51	98	16	Sa, Pa, Lu, Ao
5	58/M	0.2 g/gCr	1.20	3,170	1,204	3,960	<10	33	7	Sa, LN, Lu
6	58/M	—	1.30	1,960	1,280	456	34	81	16	Li, Ne
7	75/M	0.21 g/day	1.34	5,380	587	NA	<14	41	<5	Sa, LN, Lu
8	68/M	0.1 g/day	1.37	2,995	670	2,323	10	41	2	Sa
9	75/M	0.22 g/day	2.34	1,679	890	631	52	81	29	Sa
10	55/M	0.5 g/day	2.10	5,040	1,780	NA	49	74	36	Sa, Pa
11	69/M	0.25 g/day	2.36	4,001	1,340	NA	10	55	2	Pa
12	80/M	0.4 g/day	1.60	4,657	660	NA	<12	35	<1	Pa
13	68/M	—	1.90	3,830	736	NA	3	33	1	Sa, LN
14	79/M	—	0.60	4,756	409	457	8	41	3	Jo
15	69/M	1.0 g/gCr	7.26	4,661	1,120	335	5	10	7	La, Sa, LN, Pa, Lu, Pr
16	72/M	0.22 g/day	0.80	4,359	1,100	537	<12	55	3	LN
17	75/F	3.0 g/gCr	2.25	3,695	486	1,226	2	18	2	Sa, LN, Lu
18	83/M	2.3 g/day	1.48	3,144	944	32.1	16	56	6	—
19	60/M	0.5 g/gCr	1.59	1,952	886	575	56	86	21	La, Sa
20	78/M	1.4 g/day	6.17	3,731	1,860	NA	27.3	57	28	Pa

Note: Conversion factor for Cr: mg/dL to μmol/L, ×88.4.
Abbreviations: Ao: aorta; CH50, serum CH50 (U/mL); Cr: serum creatinine (mg/dL); C3: serum C3 (mg/dL); C4: serum C4 (mg/dL); IgG: serum immunoglobulin G (mg/dL); IgG4: serum immunoglobulin G4 (mg/dL); IgE: serum immunoglobulin E (IU/mL); Jo: joint; La: lacrimal gland; Li: liver; LN: lymph node; Lu: lung; NA: not available; Ne: nerve; Pa: pancreas; Pr: prostate; RP: retroperitoneum; Sa: salivary gland; U-Prot: proteinuria.