The Association of IL-12b Polymorphisms with Systemic Lupus Erythematosus in Chinese Han Population

Table 3

Association of IL-12b SNP rs6887695 with laboratory parameters in SLE patients*.

		Genotype frequency, no. (%)				Allele frequency, no. (%)
SNP,; population	No. of subjects	Major homozygote	Hetero-zygote	Minor homozygote	P	Major allele	Minor allele	P	OR (95% CI)
Genotype; or allele		GG	GC	CC		G	C
Total cases	297	107	153	37		367	227
Hematological; disorders
Positive	187	63	98	26	0.429	224	150	0.216	1.24 (0.88–1.76)
Negative	110	44	55	11		143	77
Proteinuria
≥0.5 g/24 h	101	35	52	14	0.851	122	80	0.617	1.09 (0.77–1.55)
<0.5 g/24 h	196	72	101	23		245	147
Antinuclear; antibody
≥1 : 320	168	67	87	14	0.032	221	115	0.022	0.68 (0.49–0.95)
<1 : 320	129	40	66	23		146	112
Anti-DNA
Positive	189	72	97	20	0.352	241	137	0.191	0.80 (0.57–1.12)
Negative	108	35	56	17		126	90
Anti-nRNP
Positive	81	31	41	9	0.846	103	59	0.581	0.90 (0.62–1.31)
Negative	216	76	112	28		264	168
Anti-Smith
Positive	68	24	37	7	0.783	85	51	0.845	0.96 (0.65–1.43)
Negative	229	83	116	30		282	176
Anti-Ro; (SSA)
Positive	118	43	61	14	0.968	147	89	0.837	0.97 (0.69–1.35)
Negative	179	64	92	23		220	138
Anti-La; (SSB)
Positive	72	25	38	9	0.963	88	56	0.848	1.04 (0.71–1.53)
Negative	225	82	115	28		279	171
C3 and C4
Decrease	133	49	79	15	0.399	177	109	0.960	0.99 (0.71–1.38)
Normal	164	58	74	22		190	118

*SNP: single-nucleotide polymorphism; SLE: systemic lupus erythematosus; OR: odds ratios; 95% CI: 95% confidence interval.